Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis
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چکیده
منابع مشابه
Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis
Fibroblast growth factor receptor 4 (FGFR4) is a member of receptor tyrosine kinase family. A functional Gly388Arg (rs351855 G>A) polymorphism in FGFR4 gene causes a glycine-to-arginine change at codon 388 within the transmembrane domain of the receptor. Although the FGFR4 rs351855 G>A polymorphism has been implicated in cancer development, its association with cancer risk remains controversial...
متن کاملFunctional FGFR4 Gly388Arg polymorphism contributes to oral squamous cell carcinoma susceptibility
Aberrations of the fibroblast growth factor receptor 4 (FGFR4) genomic region include amplification of FGFR4, activation of FGFR4 kinase domain mutations, and overexpression of FGFR4, which lead to sustained cell proliferation and contribute to tumor development. However, the association between FGFR4 single-nucleotide polymorphisms (SNPs) and risk of oral squamous cell carcinoma (OSCC) remains...
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Several studies support the hypothesis that patients’ prognosis and survival may be modulated not only by somatic alterations, but also by constitutive genetic factors. Among the few germline variations that have been associated with survival and/or clinical prognostic parameters of cancer patients is the Gly388Arg polymorphism (rs351855) of the fibroblast growth factor receptor 4 (FGFR4) that ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.15811